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Cancer • March 30, 2023, 8:51 a.m.

Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures

Medulloblastoma is a type of cancer that affects the brain and spinal cord. Recent advances in long-read sequencing technology have enabled researchers to identify a broad spectrum of structural variants in cancer genomes that drive tumorigenesis. The study of paired diagnostic and post-therapy medulloblastoma samples using long-read sequencing technology revealed the haplotype-resolved somatic genetic and epigenetic landscape, including a 1.55 Megabasepair chromothripsis event, and a complex pattern of structural variants called "templated insertion thread". The study also performed long-read based methylome profiling, identifying allele-specific methylation effects, complex rearrangements with differential methylation, and differential promoter methylation in seven cancer-driver genes. Long-read sequencing technology has the potential to reveal new diagnostic and therapeutic targets in medulloblastoma and other cancers.

Mayur_Tembhare

Cancer • Dec. 2, 2022, 3:52 p.m.

Proinflammatory activity of VEGF-targeted therapy via tumour endothelial cell anergy reversal

Cancer • April 21, 2022, 12:58 a.m.

Cellular diversity of esophageal tissue revealed

Cancer • April 19, 2022, 6:07 p.m.

Particles released by red blood cells are effective carriers for anti-cancer immunotherapy

Cancer • April 15, 2022, 8:22 p.m.

A new toolkit to engineer safe and efficient therapeutic cells

Cancer • April 15, 2022, 6:56 p.m.

Study reveals male sex hormones are new targets for cancer immunotherapy

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