The art of smell: Research suggests the brain processes smell both like a painting and a symphony

What happens when we smell a rose? How does our brain process the essence of its fragrance? Is it like a painting -- a snapshot of the flickering activity of cells -- captured in a moment in time? Or like a symphony, an evolving ensemble of different cells working together to capture the scent? New research suggests that our brain does both.

"These findings reveal a core principle of the nervous system, flexibility in the kinds of calculations the brain makes to represent aspects of the sensory world," said Krishnan Padmanabhan, Ph.D., an associate professor of Neuroscience and senior author of the study recently published in Cell Reports. "Our work provides scientists with new tools to quantify and interpret the patterns of activity of the brain."

Researchers developed a model to simulate the workings of the early olfactory system -- the network the brain relies on for smelling. Employing computer simulations, they found a specific set of connections, called centrifugal fibers, which carry impulses from other parts of the central nervous system to the early sensory regions of the brain, played a critical role. These centrifugal fibers act as a switch, toggling between different strategies to efficiently represent smells. When the centrifugal fibers were in one state, the cells in the piriform cortex -- where the perception of an odor forms -- relied on the pattern of activity within a given instant in time. When the centrifugal fibers were in the other state, the cells in the piriform cortex improved both the accuracy and the speed with which cells detected and classified the smell by relying on the patterns of brain activity across time.

These processes suggest the brain has multiple responses to representing a smell. In one strategy, the brain uses a snapshot, like a painting or a photograph, at a given moment to capture the essential features of the odor. In the other strategy, the brain keeps track of the evolving patterns. It is attuned to which cells turn on and off and when -- like a symphony.

The mathematical models the researchers developed highlight the critical feature of the nervous system -- not only diversity in terms of the components that make up the brain but also how these components work together to help the brain experience the world of smell. "These mathematical models reveal critical aspects of how the olfactory system in the brain might work and could help build brain-inspired artificial computing systems," Padmanabhan said. "Computational approaches inspired by the circuits of the brain such as this have the potential to improve the safety of self-driving cars, or help computer vision algorithms more accurately identify and classify objects in an image."

Additional authors include Zhen Chen of the University of Rochester. The research was funded by the National Institutes of Health, the National Science Foundation, the Cystinosis Research Foundation, and the Del Monte Institute for Neuroscience at the University of Rochester Pilot Program.